Product Detail
| Property | Value/Description |
|---|---|
| Molecular Formula | C22H30N6O4S |
| Molecular Weight | 474.58 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 187–189 °C |
| Boiling Point | 672.4 °C at 760 mmHg |
| Density | 1.4 ± 0.1 g/cm³ |
| Solubility | - Slightly soluble in water - Soluble in DMSO, methanol; poorly soluble in ethanol |
| LogP (Partition Coeff.) | 2.27 |
Key Applications & Functions
| Application/Industry | Description |
|---|---|
| Erectile Dysfunction (ED) | Selective inhibitor of PDE5, enhancing nitric oxide (NO)-cGMP signaling to improve penile blood flow |
| Pulmonary Arterial Hypertension (PAH) | Vasodilator approved by EMA for improving exercise capacity in PAH patients |
| Cardiovascular Diseases | Investigated for hypertension, myocardial infarction, and heart failure (preclinical/clinical studies) |
| Other Uses | Potential applications in Peyronie’s disease, visual disorders, and renal injury models |
Safety and Regulatory Notes
Contraindications: Avoid with nitrates (risk of severe hypotension) .
Metabolism: Primarily via CYP3A4 and CYP2C9 enzymes .
GHS Hazards: Flammable (GHS02), acute toxicity (GHS06), and health hazards
